Calcium hydroxide is a multipurpose agent, and there have been an increasing Some of its indications include inter-appointment intracanal medicaments. role of calcium hydroxide in the field of endodontics, focusing on its droxide can be used effectively as intracanal medicament, root canal. Calcium hydroxide (Ca(OH)2) has been widely used as an intracanal medicament for endodontic retreatment, but very few studies used both Ca(OH)2 and 1%.

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The first part of this review details the characteristics of Ca OH 2 and summarizes calcum results of in vitro studies related to its antimicrobial effect. Review of ultrasonic irrigation in endodontics: Currently, Ca OH 2 is considered the first choice of root canal dressing materials. The effects of surgical exposures of dental pulps in germ-free and inrracanal laboratory rats. Efficacy of various intracanal medicaments against Enterococcus faecalis in primary teeth: An in vitro study demonstrated that Ca OH 2 hydrolyzed the highly toxic lipid A molecule that is responsible for intracabal damaging effects of endotoxin.

To be effective against the bacteria located inside the dentinal tubules, hydroxyl ions from Ca OH 2 must diffuse through the dentin and reach sufficient levels to be lethal.

Antimicrobial Activity of Calcium Hydroxide in Endodontics: A Review

Where bone loss has occurred, the use of a root canal medicament between treatment sessions is recommended by some, 41 because the success of treatment in cases with periapical pathosis is directly related to the elimination of bacteria from the root canal system. Studies reporting antimicrobial effect of Ca OH 2 using infected dentin models with human teeth. Although some studies have supported the antimicrobial effect of Ca OH 2others have questioned its efficacy.


Antimicrobial action of calcium hydroxide, chlorhexidine and their combination on endodontic pathogens.

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Infected dentin models – bovine teeth InHaapasalo and Orstavik introduced an in vitro model for a dentinal tubule infection of the root canal. Effect of calcium hydroxide inrtacanal bacterial lipopolysaccharide. Rationale and efficacy of root canal medicaments and root filling materials with emphasis on treatment outcome. Chemical and antimicrobial properties of calcium hydroxide mixed with irrigating solutions.

The antimicrobial effect of calcium hydroxide as a short-term intracanal dressing.

Estrela C, Holland R. The in vitro antibacterial effect of iodine-potassium iodide and calcium hydroxide in infected dentinal tubules at different time intervals. Tissue-dissolution capacity and dentin-disinfecting potential of calcium hydroxide mixed with irrigating solutions.

It has been revealed that the viability of E. The antibacterial effect of camphorated paramonochlorophenol, camphorated phenol and calcium hydroxide in the treatment of infected root canals. In vitro antibacterial effect of calcium hydroxide combined with chlorhexidine or iodine potassium iodide on Enterococcus faecalis. Ca OH 2 alone was completely ineffective against C. Amorphous material filled the interbacterial spaces and was interpreted as an extracellular matrix of bacterial origin.

The purpose of endodontic therapy is to preserve the patient’s natural teeth without compromising the patient’s local or systemic health. Root canal dentinal tubule disinfection. The second carl prausnitz memorial lecture. J Clin Pediatr Dent.

Antimicrobial Activity of Calcium Hydroxide in Endodontics: A Review

Effect of calcium hydroxide on bacterial endotoxin in vivo. J Nihon Univ Sch Dent. Microorganisms isolated from root canals presenting necrotic pulp and their drug susceptibility in vitro.

All the three chelators failed to remove aqueous-based as well as oil-based Ca OH 2 completely from the root canal.

Ca OH 2 has a wide range of antimicrobial effects against common endodontic pathogens, but is less effective against Enterococcus faecalis and Candida albicans. Dentinal tubule disinfection using three calcium hydroxide formulations. Activity of endodontic antibacterial agents against selected anaerobic bacteria. Effectiveness of ultrasonics and calcium hydroxide for the debridement of human mandibular molars.


Oral Hyg Health ;2: Haapasalo M, Orstavik D. Endotoxin, which is present on all Gram-negative bacteria, is composed of polysaccharides, lipids, and proteins and is referred to as lipopolysaccharide LPSemphasizing its chemical structure.

Calcium hydroxide reduces lipopolysaccharide-stimulated osteoclast formation. An agar diffusion comparison of the antimicrobial effect zs calcium hydroxide at five different concentrations with three different vehicles.

In vitro evaluation of the antimicrobial activity of calcium hydroxide combined with chlorhexidine gel used as intracanal medicament. In conclusion, 1 The antimicrobial activity of Ca OH 2 is related to the release of highly reactive hydroxyl ions in an aqueous environment, which mainly affects cytoplasmic membranes, proteins, and DNA.

Find articles by S Shalavi. Antimicrobial efficacy of chlorhexidine and two calcium hydroxide formulations against Enterococcus faecalis. The high pH of Ca OH 2 alters the integrity of the cytoplasmic membrane by means of chemical injury to the organic components and transport of nutrients or by means of the destruction of phospholipids or unsaturated fatty acids of the cytoplasmic membrane during the peroxidation process, which is a saponification reaction.

Effectiveness of three root canal medicaments to eliminate Actinomyces israelii from infected dentinal tubules in vitro. Oxidants and human disease: The lethal effects of calcium hydroxide on bacterial cells are probably due to protein denaturation and damage to DNA and cytoplasmic membranes.

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Reddy S, Ramakrishna Y.