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The first reaction in each round of degradation is the oxidation of acyl CoA by an acyl CoA dehydrogenase to give an enoyl CoA with a trans double bond between C -2 and C A number of diseases have been traced to a deficiency of carnitine, the transferase or the translocase. Finding libraries that hold this item Carnitine Carries Long-Chain Activated Fatty Acids into the Mitochondrial Matrix Fatty acids are activated on the outer mitochondrial membrane, whereas they are oxidized in the mitochondrial matrix.

Your Web browser is not enabled for JavaScript. The hydration of enoyl CoA is a prelude to the second oxidation reaction, which converts the hydroxyl group at C -3 into a keto group and generates NADH. These diseases illustrate that the impaired flow of a metabolite from one compartment of a cell to another can lead to a pathological condition.


First, the fatty acid reacts with ATP to form an acyl adenylate. Allow this favorite library to be seen by others Keep this favorite library private.

The acyl group is transferred from the sulfur atom of CoA to the hydroxyl group of carnitine to form acyl carnitine. Subsequent work demonstrated that they are activated before they enter the mitochondrial matrix.

A saturated acyl CoA is degraded by a recurring sequence of four reactions: Reaction Sequence for the Degradation of Fatty Acids.

Turn recording back viochemia. The answer is that pyrophosphate is rapidly hydrolyzed by a pyrophosphatase, and so the complete reaction is.

Biochemia – Vicipaedia

The final step is the cleavage of 3-ketoacyl CoA by the thiol group of a second molecule of CoA, which yields acetyl CoA and an acyl CoA shortened by two carbon atoms. In adipose cells, these hormones trigger 7TM receptors that activate adenylate cyclase Section In this mixed anhydride, the carboxyl group of a biochsmia acid is bonded to the phosphoryl group of AMP.

These partial reactions are freely reversible.

Reviews User-contributed reviews Add a review and share your thoughts with other readers. The acyl group is transferred back to CoA on the matrix side of the membrane. Hence, the stoichiometry of oxidation of palmitoyl CoA is. The E-mail message field is required. The E-mail Address es field is required. Please review our privacy policy. Please enter your name. Finally, the translocase returns carnitine to the bkochemia side in exchange for an incoming acyl carnitine.



Adenosine triphosphate ATP drives the formation of a thioester linkage between the carboxyl group of a fatty acid and the sulfhydryl group of CoA. The name field is required. Acyl adenylates are frequently formed when carboxyl groups are giochemia in biochemical reactions.

Third, the fatty acids are broken down in a step-by-step fashion into acetyl CoAwhich is then processed in the citric acid cycle. However, formatting rules can vary widely between applications and fields of interest or study. In contrast, insulin inhibits lipolysis.

We see here another example of a recurring theme in biochemistry: Eugene Kennedy and Albert Lehninger showed in that fatty acids are oxidized in mitochondria. Thus, glycerol and glycolytic intermediates are readily interconvertible.

Halina Augustyniak et al.